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2
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Trehalose 6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis induces corneal angiogenesis in rats.结核分枝杆菌的海藻糖6,6'-二霉菌酸酯（索状因子）可诱导大鼠角膜血管生成。
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本文引用的文献

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EFFECT OF BACILLUS CALMETTE-GU'ERIN ON THE LEVELS OF ACID PHOSPHATASE, LYSOZYME AND CATHEPSIN IN RABBIT ALVEOLAR MACROPHAGES.卡介苗对兔肺泡巨噬细胞酸性磷酸酶、溶菌酶和组织蛋白酶水平的影响。
J Immunol. 1965 Jul;95:125-30.
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DISSOCIATION OF TUBERCULIN HYPERSENSITIVITY AS MEDIATOR FOR AN ACCELERATED PULMONARY GRANULOMATOUS RESPONSE IN RABBITS.结核菌素超敏反应作为家兔肺部加速肉芽肿反应介质的解离
J Immunol. 1964 Sep;93:433-8.
3
AN ACUTE PULMONARY GRANULOMATOUS RESPONSE IN MICE PRODUCED BY MYCOBACTERIAL CELLS AND ITS RELATION TO INCREASED RESISTANCE AND INCREASED SUSCEPTIBILITY TO EXPERIMENTAL TUBERCULOUS INFECTION.分枝杆菌细胞在小鼠中引发的急性肺肉芽肿反应及其与实验性结核感染抵抗力增强和易感性增加的关系。
J Infect Dis. 1964 Apr;114:135-51. doi: 10.1093/infdis/114.2.135.
4
A study of macrophages and epitheloid-like cells from granulomatous (BCG-induced) lungs of rabbits.对兔肉芽肿性（卡介苗诱导）肺组织中的巨噬细胞和上皮样细胞的研究。
J Immunol. 1962 Nov;89:745-51.
5
Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6-dimycolate (cord factor) and living bacillus Calmette Guérin.用海藻糖-6,6-二霉菌酸酯（索状因子）和活卡介苗治疗的小鼠中，对乌拉坦诱导的肺腺瘤的抑制作用
Science. 1971 Dec 17;174(4015):1240-2. doi: 10.1126/science.174.4015.1240.
6
Recent studies on acquired immunity in tuberculosis.近期关于结核病获得性免疫的研究。
Curr Top Microbiol Immunol. 1969;48:129-78. doi: 10.1007/978-3-642-46163-7_6.
7
Granuloma formation induced in mice by chemically defined mycobacterial fractions.化学定义的分枝杆菌组分在小鼠中诱导形成肉芽肿。
J Bacteriol. 1969 Oct;100(1):95-102. doi: 10.1128/jb.100.1.95-102.1969.
8
Effects of oil-treated mycobacterial cell walls on the organs of mice.经油处理的分枝杆菌细胞壁对小鼠器官的影响。
J Bacteriol. 1967 Nov;94(5):1736-45. doi: 10.1128/jb.94.5.1736-1745.1967.
9
Immune response to sheep red blood cells in mice pretreated with mycobacterial fractions.用分枝杆菌组分预处理的小鼠对绵羊红细胞的免疫反应。
Infect Immun. 1971 Sep;4(3):256-63. doi: 10.1128/iai.4.3.256-263.1971.
10
Cellular reaction in the footpad and draining lymph nodes of mice induced by mycobacterial fractions and BCG bacilli.分枝杆菌组分和卡介苗杆菌诱导的小鼠足垫及引流淋巴结中的细胞反应。
Infect Immun. 1971 Sep;4(3):245-55. doi: 10.1128/iai.4.3.245-255.1971.

感染卡介苗的小鼠对海藻糖-6,6'-二霉菌酸酯（索状因子）的肉芽肿性超敏反应。

Granulomatous hypersensitivity to trehalose-6,6'-dimycolate (cord factor) in mice infected with BCG.

作者信息

Bekierkunst A, Yarkoni E

出版信息

Infect Immun. 1973 Apr;7(4):631-8. doi: 10.1128/iai.7.4.631-638.1973.

DOI:10.1128/iai.7.4.631-638.1973
PMID:4586862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422736/
Abstract

Cord factor in the form of emulsion is unable to sensitize mice to react with a more extensive granulomatous response to a subsequent challenge with the same substance. Mice infected with BCG bacilli are sensitized to cord factor. Such animals react to administration of cord factor with a very extensive granulomatous response, much stronger than normal ones. This hypersensitivity seems to be specific and is distinct from delayed hypersensitivity to PPD. PPD, administered to mice sensitized with BCG bacilli, has no effect on the granulomatous response. Our findings and their importance are discussed.

摘要

乳剂形式的索状因子无法使小鼠致敏，从而对随后用相同物质进行的攻击产生更广泛的肉芽肿反应。感染卡介苗杆菌的小鼠对索状因子致敏。这类动物对索状因子的给药会产生非常广泛的肉芽肿反应，比正常动物的反应强烈得多。这种超敏反应似乎具有特异性，且与对结核菌素纯蛋白衍生物（PPD）的迟发型超敏反应不同。给用卡介苗杆菌致敏的小鼠注射PPD，对肉芽肿反应没有影响。我们对研究结果及其重要性进行了讨论。