感染卡介苗的小鼠对海藻糖-6,6'-二霉菌酸酯（索状因子）的肉芽肿性超敏反应。
Granulomatous hypersensitivity to trehalose-6,6'-dimycolate (cord factor) in mice infected with BCG.
作者信息
Bekierkunst A, Yarkoni E
出版信息
Infect Immun. 1973 Apr;7(4):631-8. doi: 10.1128/iai.7.4.631-638.1973.
Abstract
Cord factor in the form of emulsion is unable to sensitize mice to react with a more extensive granulomatous response to a subsequent challenge with the same substance. Mice infected with BCG bacilli are sensitized to cord factor. Such animals react to administration of cord factor with a very extensive granulomatous response, much stronger than normal ones. This hypersensitivity seems to be specific and is distinct from delayed hypersensitivity to PPD. PPD, administered to mice sensitized with BCG bacilli, has no effect on the granulomatous response. Our findings and their importance are discussed.
摘要
乳剂形式的索状因子无法使小鼠致敏，从而对随后用相同物质进行的攻击产生更广泛的肉芽肿反应。感染卡介苗杆菌的小鼠对索状因子致敏。这类动物对索状因子的给药会产生非常广泛的肉芽肿反应，比正常动物的反应强烈得多。这种超敏反应似乎具有特异性，且与对结核菌素纯蛋白衍生物（PPD）的迟发型超敏反应不同。给用卡介苗杆菌致敏的小鼠注射PPD，对肉芽肿反应没有影响。我们对研究结果及其重要性进行了讨论。
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1
2
3
AN ACUTE PULMONARY GRANULOMATOUS RESPONSE IN MICE PRODUCED BY MYCOBACTERIAL CELLS AND ITS RELATION TO INCREASED RESISTANCE AND INCREASED SUSCEPTIBILITY TO EXPERIMENTAL TUBERCULOUS INFECTION.分枝杆菌细胞在小鼠中引发的急性肺肉芽肿反应及其与实验性结核感染抵抗力增强和易感性增加的关系。
J Infect Dis. 1964 Apr;114:135-51. doi: 10.1093/infdis/114.2.135.
4
5
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6
Recent studies on acquired immunity in tuberculosis.近期关于结核病获得性免疫的研究。
Curr Top Microbiol Immunol. 1969;48:129-78. doi: 10.1007/978-3-642-46163-7_6.
7
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8
Effects of oil-treated mycobacterial cell walls on the organs of mice.经油处理的分枝杆菌细胞壁对小鼠器官的影响。
J Bacteriol. 1967 Nov;94(5):1736-45. doi: 10.1128/jb.94.5.1736-1745.1967.
9
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10
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