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麻风分枝杆菌的佐剂活性。

Adjuvant activity of Mycobacterium leprae.

作者信息

Stewart-Tull D E, Davies M

出版信息

Infect Immun. 1972 Dec;6(6):909-12. doi: 10.1128/iai.6.6.909-912.1972.

DOI:10.1128/iai.6.6.909-912.1972
PMID:4565054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC419311/
Abstract

Mycobacterium leprae organisms isolated from infected spleen and liver tissue by zonal centrifugation were shown to possess adjuvant activity. Histochemical examination of the footpad macrophage epithelioid granuloma showed that macrophages contained large amounts of hemosiderin after the injection of M. leprae and much smaller amounts after the injection of M. tuberculosis.

摘要

通过区带离心从受感染的脾脏和肝脏组织中分离出的麻风分枝杆菌被证明具有佐剂活性。对足垫巨噬细胞上皮样肉芽肿的组织化学检查表明，注射麻风分枝杆菌后巨噬细胞含有大量含铁血黄素，而注射结核分枝杆菌后含铁血黄素量要少得多。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/419311/50788c4d337f/iai00276-0019-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/419311/21860add7221/iai00276-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/419311/7738f355b6ac/iai00276-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/419311/50788c4d337f/iai00276-0019-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/419311/21860add7221/iai00276-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/419311/7738f355b6ac/iai00276-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/419311/50788c4d337f/iai00276-0019-b.jpg

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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Studies on antibody production. IV. The role of a wax fraction of Mycobacterium tuberculosis in adjuvant emulsions on the production of antibody to egg albumin.抗体产生的研究。IV. 结核分枝杆菌蜡质部分在佐剂乳剂中对卵清蛋白抗体产生的作用。
J Exp Med. 1955 Jul 1;102(1):83-104. doi: 10.1084/jem.102.1.83.
3
CORRELATION OF ADJUVANT ACTIVITY AND CHEMICAL STRUCTURE OF WAX D FRACTIONS OF MYCOBACTERIA.分枝杆菌蜡质D组分的佐剂活性与化学结构的相关性
九带犰狳（Dasypus novemcinctus Linn.）与人类血清蛋白和水溶性肝组织抗原之间的交叉反应。
Clin Exp Immunol. 1979 Oct;38(1):135-47.
4
Immunity to Mycobacterium leprae infections in mice stimulated by M. leprae, BCG, and graft-versus-host reactions.麻风杆菌、卡介苗及移植物抗宿主反应刺激小鼠产生的对麻风杆菌感染的免疫力。
Infect Immun. 1976 Oct;14(4):919-28. doi: 10.1128/iai.14.4.919-928.1976.
Immunology. 1964 Mar;7(2):158-71.
4
The influence of components of M. tuberculosis and other Mycobacteria upon antibody production to ovalbumin.结核分枝杆菌及其他分枝杆菌的成分对卵清蛋白抗体产生的影响。
Immunology. 1958 Jan;1(1):54-66.
5
The role of tubercle bacilli in adjuvant emulsions on antibody production to egg albumin.结核杆菌在佐剂乳剂中对卵白蛋白抗体产生的作用。
J Immunol. 1952 Dec;69(6):611-8.
6
The influence of age of culture on the production of adjuvant-active peptidoglycolipids by saprophytic mycobacteria.培养物年龄对腐生分枝杆菌产生佐剂活性肽糖脂的影响。
Immunology. 1967 Mar;12(3):349-59.
7
Surface peptido-glycolipid filaments on Mycobacterium leprae.麻风分枝杆菌表面的肽糖脂细丝。
Clin Exp Immunol. 1971 Oct;9(4):539-47.