Jordan G W
Infect Immun. 1973 Jun;7(6):911-7. doi: 10.1128/iai.7.6.911-917.1973.
Two strains of Venezuelan equine encephalomyelitis virus, which differ in virulence for mice, have been studied for their production of and sensitivity to chick and mouse interferon. Little interferon was produced by chick cells in response to the virulent Trinidad strain or the attenuated TC-83 strain without either aging or priming the cultures. Consistent differences in the production of chick interferon were not found between the two strains. Plaque variants of the Trinidad strain produced higher titers of mouse interferon than the TC-83 strain in both primed and control L-cell cultures. The TC-83 strain was found to be more sensitive than the Trinidad strain to the inhibitory effects of interferon. The greater sensitivity of the TC-83 strain was observed at both high and low multiplicities and for both chick and mouse interferons. These results are consistent with the hypothesis that interferon sensitivity may have a role as a determinant of virulence in some virus-host systems.
对两株对小鼠毒力不同的委内瑞拉马脑炎病毒进行了研究，观察它们产生鸡和小鼠干扰素的情况以及对干扰素的敏感性。未对培养物进行老化或预处理时，鸡细胞对强毒力的特立尼达毒株或减毒的TC - 83毒株反应产生的干扰素很少。两株病毒在鸡干扰素产生方面未发现一致的差异。在预处理和对照的L细胞培养物中，特立尼达毒株的空斑变异株产生的小鼠干扰素滴度均高于TC - 83毒株。发现TC - 83毒株比特立尼达毒株对干扰素的抑制作用更敏感。在高、低感染复数条件下以及对鸡和小鼠干扰素，均观察到TC - 83毒株具有更高的敏感性。这些结果与以下假设一致，即在某些病毒 - 宿主系统中，干扰素敏感性可能作为毒力的一个决定因素发挥作用。
