自调节：一种生物合成酶在基因表达调控中的作用。
Autoregulation: a role for a biosynthetic enzyme in the control of gene expression.
作者信息
Calhoun D H, Hatfield G W
出版信息
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2757-61. doi: 10.1073/pnas.70.10.2757.
Abstract
It was previously proposed, primarily on the basis of evidence in vitro, that L-threonine deaminase, the ilvA gene product, is required for repression of its own synthesis and for repression of the other genes in the ilv-ADE operon. In this communication, evidence in vivo is presented that supports this autoregulatory model. Further evidence is presented that suggests that L-threonine deaminase is also required for induction of the ilvC gene product. The autoregulatory model is presented in an expanded form to include recent evidence that L-threonine deaminase (EC 4.2.1.16) is a central element for repression of the ilvADE and ilvB operons, and for induction of the ilvC operon.
摘要
之前主要基于体外实验证据提出，ilvA基因产物L-苏氨酸脱氨酶是其自身合成的阻遏以及ilv-ADE操纵子中其他基因阻遏所必需的。在本论文中，给出了支持这一自动调节模型的体内实验证据。还给出了进一步的证据，表明L-苏氨酸脱氨酶也是ilvC基因产物诱导所必需的。自动调节模型以扩展形式呈现，纳入了最近的证据，即L-苏氨酸脱氨酶（EC 4.2.1.16）是ilvADE和ilvB操纵子阻遏以及ilvC操纵子诱导的核心元件。
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Isoleucine auxotrophy as a consequence of a mutationally altered isoleucyl-transfer ribonucleic acid synthetase.由于异亮氨酰 - 转移核糖核酸合成酶发生突变而导致的异亮氨酸营养缺陷。
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