Fc片段诱导的小鼠脾细胞增殖反应中贴壁细胞的需求。
The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells.
作者信息
Morgan E L, Weigle W O
出版信息
J Exp Med. 1979 Aug 1;150(2):256-66. doi: 10.1084/jem.150.2.256.
Abstract
The proliferative response of mouse B lymphocytes induced by Fc fragments was found to be dependent upon an adherent cell population. The adherent cell is esterase positive, irradiation resistant, and not susceptible to lysis by anti-thymus serum and complement. The mechanism(s) by which Fc fragments induce B-cell proliferation could be the result of the interaction of Fc with both B cells and adherent cells or with adherent cells which then release factors that trigger the B cells to proliferate. Spleen cells from the C3H/HeJ mouse were shown to be unable to respond to Fc fragments. The addition of adherent cells from either C3H/St or C3H/HeN mice to adherent cell depleted C3H/HeJ cells enabled them to respond to Fc, indicating the defect was in the adherent cell population.
摘要
发现Fc片段诱导的小鼠B淋巴细胞增殖反应依赖于贴壁细胞群体。该贴壁细胞酯酶呈阳性，抗辐射，且不易被抗胸腺血清和补体裂解。Fc片段诱导B细胞增殖的机制可能是Fc与B细胞和贴壁细胞相互作用的结果，或者是与贴壁细胞相互作用，然后贴壁细胞释放触发B细胞增殖的因子。已证明C3H/HeJ小鼠的脾细胞对Fc片段无反应。将来自C3H/St或C3H/HeN小鼠的贴壁细胞添加到去除贴壁细胞的C3H/HeJ细胞中，使其能够对Fc产生反应，这表明缺陷在于贴壁细胞群体。
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