Fc片段对人B淋巴细胞的多克隆激活。I.人外周血B淋巴细胞通过Fc片段介导多克隆抗体分泌的细胞需求特征
Polyclonal activation of human B lymphocytes by Fc fragments. I. Characterization of the cellular requirements for Fc fragment-mediated polyclonal antibody secretion by human peripheral blood B lymphocytes.
作者信息
Morgan E L, Weigle W O
出版信息
J Exp Med. 1981 Sep 1;154(3):778-90. doi: 10.1084/jem.154.3.778.
Abstract
Fc fragments derived from human immunoglobulin were found to be capable of inducing both a proliferative and polyclonal antibody response in human peripheral blood lymphocyte cultures. The cell population proliferating in response to Fc fragments belongs to the B cell lineage. Expression of polyclonal antibody formation requires the presence of both adherent monocytes and T cells. The role of the monocyte is to enzymatically cleave the Fc fragment into 19,000 mol wt Fc subfragments that are then able to induce polyclonal antibody secretion. Stimulation of polyclonal antibody production by Fc subfragments occurs in the absence of adherent monocytes but still requires the presence of T cells.
摘要
人们发现，源自人免疫球蛋白的Fc片段能够在人外周血淋巴细胞培养物中诱导增殖反应和多克隆抗体反应。对Fc片段产生增殖反应的细胞群体属于B细胞谱系。多克隆抗体形成的表达需要贴壁单核细胞和T细胞同时存在。单核细胞的作用是将Fc片段酶解为分子量为19,000的Fc亚片段，这些亚片段随后能够诱导多克隆抗体分泌。Fc亚片段在不存在贴壁单核细胞的情况下也能刺激多克隆抗体产生，但仍需要T细胞的存在。
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