恶性疟疾中的促红细胞生成素生成
Erythropoietin production in virulent malaria.
作者信息
Rencricca N J, Stout J P, Coleman R M
出版信息
Infect Immun. 1974 Oct;10(4):831-3. doi: 10.1128/iai.10.4.831-833.1974.
Abstract
Erythropoietin, the hormone responsible for stimulating erythrocyte production, was shown to increase significantly in the serum of mice during virulent malaria infection. Although erythropoiesis was enhanced, it did not keep pace with the rate of erythocyte destruction; hence all Plasmodium berghei-infected mice quickly succumbed to the deleterious consequences of severe uncompensated hemolytic anemia. Since this apparently inadequate rate of erythropoiesis is not attributed to impaired erythropoietin generation, mechanisms relating to (i) hemopoietic stem-cell resistance to endogenous erythropoietin, (ii) deficits in numbers of hemopoietic stem cells, and/or (iii) ineffective erythropoiesis are of interest.
摘要
促红细胞生成素是一种负责刺激红细胞生成的激素，研究表明，在恶性疟疾感染期间，小鼠血清中的促红细胞生成素显著增加。虽然红细胞生成有所增强，但它跟不上红细胞破坏的速度；因此，所有感染伯氏疟原虫的小鼠很快就死于严重失代偿性溶血性贫血的有害后果。由于这种明显不足的红细胞生成速率并非归因于促红细胞生成素生成受损，因此与以下方面相关的机制值得关注：（i）造血干细胞对内源性促红细胞生成素的抗性；（ii）造血干细胞数量不足；和/或（iii）无效的红细胞生成。
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