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人类细胞毒性B淋巴细胞的选择性缺陷。

Selective deficiency of cytotoxic B lymphocytes in man.

作者信息

Campbell A C, Maclennan I C, Snaith M L, Barnett I G

出版信息

Clin Exp Immunol. 1972 Sep;12(1):1-8.

PMID:4628403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553647/
Abstract

A patient is described with macroglobulinaemia, a variety of autoantibodies, and gross deficiency of lymphocytes showing cytotoxicity against antibody-sensitized target cells . Antibody production in response to tetanus toxoid, delayed hypersensitivity to tuberculin, and lymphocyte transformation with phytohaemagglutinin are normal. The patient's macrophages have normal phagocytic activity against sensitized sheep red cells. These results are contrasted with those found in other patients with myeloma and macroglobulinaemia. The application of lymphocyte function tests in the assessment of immunological status is discussed.

摘要

本文描述了一名患有巨球蛋白血症、多种自身抗体以及淋巴细胞严重缺乏且对抗体致敏靶细胞无细胞毒性的患者。该患者对破伤风类毒素的抗体产生、对结核菌素的迟发型超敏反应以及用植物血凝素进行的淋巴细胞转化均正常。患者的巨噬细胞对致敏绵羊红细胞具有正常的吞噬活性。这些结果与其他骨髓瘤和巨球蛋白血症患者的结果形成对比。文中还讨论了淋巴细胞功能测试在评估免疫状态中的应用。

相似文献

1
Selective deficiency of cytotoxic B lymphocytes in man.人类细胞毒性B淋巴细胞的选择性缺陷。
Clin Exp Immunol. 1972 Sep;12(1):1-8.
2
Clinical assessment of T and B lymphocyte functions.T和B淋巴细胞功能的临床评估。
R I Med J (1976). 1976 Feb;59(2):51-6, 71.
3
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Lymphocyte-monocyte defect associated with anergy and recurrent infections.与无反应性和反复感染相关的淋巴细胞-单核细胞缺陷。
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Human thymus lymphoid tissue (HTL) antigen, complement receptor and rosette formation with sheep erythrocytes of the lymphocytes from primary immunodeficiency diseases.人类胸腺淋巴组织（HTL）抗原、补体受体以及原发性免疫缺陷疾病患者淋巴细胞与绵羊红细胞的玫瑰花结形成。
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Immune function in patients with multiple myeloma (delayed cutaneous reactivity and lymphocytes bearing receptors for sheep, human and mouse erythrocytes).多发性骨髓瘤患者的免疫功能（迟发性皮肤反应以及带有绵羊、人类和小鼠红细胞受体的淋巴细胞）
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8
[Antigen recognition].[抗原识别]
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Antibody deficiency syndrome in patients with multiple myeloma and macroglobulinemia Waldenström.
Helv Med Acta. 1972 Apr;36(2):201-2.
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[T and B lymphocytes in humans. Lymphocytes with membrane immunoglobulins in normal and pathological conditions].[人类的T淋巴细胞和B淋巴细胞。正常及病理状态下带有膜免疫球蛋白的淋巴细胞]
Recenti Prog Med. 1973 Feb;54(2):124-51.

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Antibody-dependent direct cytotoxicity of human lymphocytes. II. Studies on peripheral blood lymphocytes, synovial fluid cells and sera from patients with rheumatoid arthritis.人淋巴细胞的抗体依赖性直接细胞毒性。II. 对类风湿性关节炎患者外周血淋巴细胞、滑液细胞及血清的研究。
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8
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本文引用的文献

1
CONTACT-INDUCED CYTOTOXICITY BY LYMPHOID CELLS CONTAINING FOREIGN ISOANTIGENS.含有外来同种抗原的淋巴细胞引起的接触性细胞毒性
Science. 1965 Feb 19;147(3660):873-9. doi: 10.1126/science.147.3660.873.
2
Tetanus antitoxin titration by haemagglutination.通过血凝反应进行破伤风抗毒素滴定
J Hyg (Lond). 1957 Sep;55(3):382-401. doi: 10.1017/s0022172400037293.
3
Impaired phytohaemagglutinin-induced cytotoxicity in vitro of lymphocytes from patients with Hodgkin's disease or chronic lymphatic leukaemia.霍奇金病或慢性淋巴细胞白血病患者淋巴细胞在体外对植物血凝素诱导的细胞毒性受损。
Clin Exp Immunol. 1967 May;2(3):351-60.
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Purification of lymphocytes and platelets by gradient centrifugation.通过梯度离心法纯化淋巴细胞和血小板。
J Lab Clin Med. 1968 Nov;72(5):842-8.
5
The establishment of a normal human population dose-response curve for lymphocytes cultured with PHA (phytohaemagglutinin).用植物血凝素（PHA）培养淋巴细胞的正常人群剂量反应曲线的建立。
Clin Exp Immunol. 1971 Mar;8(3):421-5.
6
Failure of certain cytotoxic lymphocytes to respond mitotically to phytohaemagglutinin.某些细胞毒性淋巴细胞对植物血凝素的有丝分裂反应失败。
Nature. 1970 Sep 19;227(5264):1246-8. doi: 10.1038/2271246a0.
7
Cytotoxic lymphocytes from rats depleted of thymus processed cells.来自胸腺处理细胞耗竭的大鼠的细胞毒性淋巴细胞。
Nat New Biol. 1971 Jul 21;232(29):80-2. doi: 10.1038/newbio232080a0.
8
In vitro cytotoxicity of lymphocytes from patients with "acquired" and sex-linked agammaglobulinaemia.“获得性”及性连锁无丙种球蛋白血症患者淋巴细胞的体外细胞毒性
Clin Exp Immunol. 1971 Nov;9(5):603-9.
9
The thymus and circulating lymphocytes of mice.
Proc R Soc Lond B Biol Sci. 1970 Oct 13;176(1042):69-85. doi: 10.1098/rspb.1970.0035.
10
Induction of cytotoxicity of lymphocytes from tolerant donors by antibodies to target cell alloantigens.通过针对靶细胞同种异体抗原的抗体诱导来自耐受供体的淋巴细胞的细胞毒性。
Transplantation. 1970 Oct;10(4):290-6.

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