对一种类似于农民肺的牛呼吸道疾病（“urner肺炎”）的血清学调查。
Serological investigations of a bovine respiratory disease ("urner pneumonie") resembling farmer's lung.
作者信息
Nicolet J, de Haller R, Herzog J
出版信息
Infect Immun. 1972 Jul;6(1):38-42. doi: 10.1128/iai.6.1.38-42.1972.
The immunological response of cattle exposed to moldy hay was examined by agar gel diffusion with standard farmer's lung hay antigens. A high incidence of precipitins against Micropolyspora faeni (60%) and moldy hay antigen (80%) was detected in exposed but apparently healthy cattle from a region with a high incidence of bovine farmer's lung. In comparison, in the plains, a low incidence area, we found only 1 animal of 164 harboring precipitins against M. faeni. We further observed that many animals from exposed populations lost their precipitins during pasturing and regained them during winter housing. Thirty-nine clinical cases of bovine farmer's lung ("Urner Pneumonie") were investigated serologically. Only 49% of these animals showed precipitins against M. faeni and 54% showed precipitins against moldy hay antigen. We discuss in this paper the probable causes of this apparent lack of immunological response.
通过用标准农民肺干草抗原进行琼脂凝胶扩散试验，检测了接触发霉干草的牛的免疫反应。在一个牛农民肺发病率高的地区，对接触过但表面健康的牛进行检测，发现针对嗜热放线多孢菌的沉淀素发生率很高（60%），针对发霉干草抗原的沉淀素发生率也很高（80%）。相比之下，在发病率低的平原地区，我们发现164只动物中只有1只带有针对嗜热放线多孢菌的沉淀素。我们进一步观察到，许多接触过的动物在放牧期间失去了沉淀素，而在冬季圈养期间又重新获得了沉淀素。对39例牛农民肺临床病例（“乌尔纳肺炎”）进行了血清学调查。这些动物中只有49%显示出针对嗜热放线多孢菌的沉淀素，54%显示出针对发霉干草抗原的沉淀素。我们在本文中讨论了这种明显缺乏免疫反应的可能原因。
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