Fletcher S M, Rondle C J, Murray I G
J Hyg (Lond). 1970 Sep;68(3):401-9. doi: 10.1017/s0022172400042303.
A serological analysis of the extracellular antigens of Micropolyspora faeni by immunodiffusion with a combination of sera revealed 29 individual antigens. A survey was made of the incidence of precipitins to the antigens in sera from patients with clinical farmer's lung disease (FLD) and other respiratory diseases. Precipitating antibody was found in 75% of farmer's lung cases and in 20% of other cases who had been exposed to the same environment. More precipitin reactions were seen in sera from severe forms of FLD than from milder forms. The distribution of precipitins to individual antigens was not significantly affected by severity of disease.Most of the patients with precipitins to M. faeni, but without the symptoms of FLD, were suffering from mild or moderate symptoms of other respiratory diseases with a history of chronic onset of symptoms. The distribution of precipitins to individual antigens in this group was similar to that in clinical FLD patients but the incidence was considerably lower.The significance of these results is discussed.
采用混合血清免疫扩散法对嗜热放线多孢菌的细胞外抗原进行血清学分析，共发现29种单一抗原。对临床农民肺疾病（FLD）患者及其他呼吸系统疾病患者血清中针对这些抗原的沉淀素发生率进行了调查。在75%的农民肺病例以及20%曾暴露于相同环境的其他病例血清中发现了沉淀抗体。与轻症农民肺疾病患者相比，重症患者血清中出现的沉淀反应更多。疾病严重程度对针对单一抗原的沉淀素分布没有显著影响。大多数针对嗜热放线多孢菌有沉淀素但无农民肺疾病症状的患者，患有其他呼吸系统疾病的轻、中度症状，且症状有慢性发作史。该组中针对单一抗原的沉淀素分布与临床农民肺疾病患者相似，但发生率要低得多。对这些结果的意义进行了讨论。
