Jameson J E
J Clin Pathol. 1969 Sep;22(5):519-26. doi: 10.1136/jcp.22.5.519.
Immunodiffusion, immunoosmophoresis, and precipitin inhibition tests were carried out on various categories of sera with extracts of Micropolyspora faeni (Thermopolyspora polyspora), Aspergillus fumigatus, and Thermoactinomyces vulgaris. The sera were from clinical cases of farmer's lung, from symptomless farm workers, from expectant mothers, from tuberculous and from asthmatic patients, and from patients with miscellaneous lung disorders. The clinical cases of farmer's lung became divisible into two groups by serological tests for antibody to a particular soluble antigenic component of M. faeni. The suggestion is made that one of these two groups of cases may be aetiologically unrelated to M. faeni. One of six sera tested in this group reacted strongly with an extract of T. vulgaris. Antibodies to certain components of some extracts of M. faeni and of A. fumigatus were found in a high proportion of normal sera. Possible reasons for this finding have been given.
对来自农民肺临床病例、无症状农场工人、孕妇、肺结核患者、哮喘患者以及患有其他肺部疾病患者的各类血清，使用嗜热放线多孢菌（嗜热栖热放线菌）、烟曲霉和普通嗜热放线菌的提取物进行了免疫扩散、免疫渗透电泳和沉淀抑制试验。通过针对嗜热放线多孢菌特定可溶性抗原成分的抗体血清学检测，农民肺临床病例可分为两组。有人提出这两组病例中的一组可能在病因上与嗜热放线多孢菌无关。该组检测的六份血清中有一份与普通嗜热放线菌的提取物发生强烈反应。在高比例的正常血清中发现了针对嗜热放线多孢菌和烟曲霉某些提取物特定成分的抗体。已给出这一发现的可能原因。
