妥布霉素与其他氨基糖苷类药物相比的体外活性。
The in-vitro activity of tobramycin compared with that of other aminoglycosides.
作者信息
Waterworth P M
出版信息
J Clin Pathol. 1972 Nov;25(11):979-83. doi: 10.1136/jcp.25.11.979.
Abstract
The influence of medium composition, pH, serum, and magnesium on the action of tobramycin is compared to that on the action of gentamicin. The minimum inhibitory concentration of tobramycin, gentamicin, kanamycin, and streptomycin was determined for 472 strains including 19 species: tobramycin was found to be the most active against Ps. aeruginosa and kanamycin against Providence, but gentamicin was usually the most active against all other species. Ps. aeruginosa passaged on medium containing either gentamicin or tobramycin showed increased resistance to both. Sensitive strains of this species were shown to contain a small minority of cells resistant to these antibiotics, the presence of which is believed to account for the marked bactericidal synergy which was demonstrated between tobramycin and carbenicillin.
摘要
将培养基成分、pH值、血清和镁对妥布霉素作用的影响与它们对庆大霉素作用的影响进行了比较。测定了包括19个菌种的472株菌株对妥布霉素、庆大霉素、卡那霉素和链霉素的最低抑菌浓度：发现妥布霉素对铜绿假单胞菌活性最强，卡那霉素对普罗威登斯菌活性最强，但庆大霉素通常对所有其他菌种活性最强。在含有庆大霉素或妥布霉素的培养基上传代的铜绿假单胞菌对二者的耐药性均增加。该菌种的敏感菌株显示含有一小部分对这些抗生素耐药的细胞，据信这些细胞的存在解释了妥布霉素和羧苄西林之间显著的杀菌协同作用。
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