孕妇吸烟习惯与先天性畸形：一项人群研究。
Maternal smoking habits and congenital malformations: a population study.
作者信息
Evans D R, Newcombe R G, Campbell H
出版信息
Br Med J. 1979 Jul 21;2(6183):171-3. doi: 10.1136/bmj.2.6183.171.
Abstract
Maternal smoking habits in 67 609 singleton pregnancies were examined. The overall incidence of congenital malformations was 2.8% in both non-smokers and smokers. On analysing congenital defects according to individual systems there was no significant difference in the incidence of malformations according to the number of cigarettes smoked, except for neural tube defects. Further analysis, taking social class into account, showed that neural tube defects were less common in non-smokers in social classes I and II. This study suggests that maternal smoking does not have teratogenic effects in the offspring, except in the case of neural tube defects, where the effect is at most modest.
摘要
对67609例单胎妊娠的孕妇吸烟习惯进行了调查。非吸烟者和吸烟者的先天性畸形总体发生率均为2.8%。根据各个系统分析先天性缺陷时，除神经管缺陷外，畸形发生率根据吸烟数量并无显著差异。进一步分析并考虑社会阶层后发现，社会阶层I和II的非吸烟者中神经管缺陷较少见。这项研究表明，除神经管缺陷外，孕妇吸烟对后代没有致畸作用，而神经管缺陷的影响至多也不大。
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