兔盲肠和结肠利用丁酸和乙酸进行生酮作用。
Ketogenesis from butyrate and acetate by the caecum and the colon of rabbits.
作者信息
Henning S J, Hird F J
出版信息
Biochem J. 1972 Dec;130(3):785-90. doi: 10.1042/bj1300785.
Abstract
- When studied in vitro, tissue from the caecum and the proximal colon of rabbits converted butyrate into ketone bodies. The conversion was similar to that observed with liver slices. The ketogenic activity was associated with the mucosa rather than the muscle of the gut wall and, in the colon, diminished as the distance from the caecal-colonic junction increased. 2. Tissue from the wall of the ileum, caecum, proximal colon and distal colon was also shown to metabolize [1-(14)C]butyrate to carbon dioxide. 3. Enzyme assays showed that in both liver tissue and caecal mucosa the activity of hydroxymethylglutaryl-CoA synthase was more than ten times that of acetoacetyl-CoA deacylase. Labelling experiments in vitro gave confirmation of the hydroxymethylglutaryl-CoA pathway. 4. The significance of the conversion of butyrate into ketone bodies is discussed.
摘要
- 在体外研究时，兔盲肠和近端结肠组织可将丁酸转化为酮体。这种转化与肝切片中观察到的情况相似。生酮活性与肠壁的黏膜而非肌肉相关，并且在结肠中，随着距盲肠 - 结肠交界处距离的增加而降低。2. 回肠、盲肠、近端结肠和远端结肠壁的组织也被证明可将[1-(14)C]丁酸代谢为二氧化碳。3. 酶分析表明，在肝组织和盲肠黏膜中，羟甲基戊二酰辅酶A合酶的活性均比乙酰乙酰辅酶A脱酰酶的活性高十多倍。体外标记实验证实了羟甲基戊二酰辅酶A途径。4. 讨论了丁酸转化为酮体的意义。
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本文引用的文献
1
The metabolism of short-chain fatty acids in the sheep. I. Fatty acid utilization and ketone body production by rumen epithelium and other tissues.绵羊体内短链脂肪酸的代谢。I. 瘤胃上皮及其他组织对脂肪酸的利用和酮体生成
Biochem J. 1952 May;51(2):251-8. doi: 10.1042/bj0510251.
2
The metabolism of glucose and butyrate by the omasum of the sheep.绵羊皱胃对葡萄糖和丁酸的代谢
Biochim Biophys Acta. 1959 Oct;35:422-34. doi: 10.1016/0006-3002(59)90392-0.
3
Synthesis of acetoacetate by liver enzymes.
J Biol Chem. 1963 Jan;238:64-8.
4
Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.血液中D(-)-β-羟基丁酸和乙酰乙酸的酶法测定
Biochem J. 1962 Jan;82(1):90-6. doi: 10.1042/bj0820090.
5
The mechanism of ketone-body formation from butyrate in rat liver.大鼠肝脏中丁酸生成酮体的机制。
Biochem J. 1962 Jul;84(1):212-6. doi: 10.1042/bj0840212.
6
Movements of fluid and glucose in an everted sac preparation of rat colonic mucosa.大鼠结肠黏膜外翻囊制备物中液体和葡萄糖的转运
Biochim Biophys Acta. 1960 Jun 17;41:173-5. doi: 10.1016/0006-3002(60)90393-0.
7
8
The mode of formation of ketone bodies from butyrate by tissue from the rumen and omasum of the sheep.绵羊瘤胃和网胃组织将丁酸转化为酮体的形成方式。
Biochim Biophys Acta. 1961 Jan 29;46:457-67. doi: 10.1016/0006-3002(61)90577-7.
9
10
[The chemical mechanism of acetic acid formation in the liver].[肝脏中乙酸形成的化学机制]
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