兔盲肠和结肠利用丁酸和乙酸进行生酮作用。
Ketogenesis from butyrate and acetate by the caecum and the colon of rabbits.
作者信息
Henning S J, Hird F J
出版信息
Biochem J. 1972 Dec;130(3):785-90. doi: 10.1042/bj1300785.
Abstract
- When studied in vitro, tissue from the caecum and the proximal colon of rabbits converted butyrate into ketone bodies. The conversion was similar to that observed with liver slices. The ketogenic activity was associated with the mucosa rather than the muscle of the gut wall and, in the colon, diminished as the distance from the caecal-colonic junction increased. 2. Tissue from the wall of the ileum, caecum, proximal colon and distal colon was also shown to metabolize [1-(14)C]butyrate to carbon dioxide. 3. Enzyme assays showed that in both liver tissue and caecal mucosa the activity of hydroxymethylglutaryl-CoA synthase was more than ten times that of acetoacetyl-CoA deacylase. Labelling experiments in vitro gave confirmation of the hydroxymethylglutaryl-CoA pathway. 4. The significance of the conversion of butyrate into ketone bodies is discussed.
摘要
- 在体外研究时，兔盲肠和近端结肠组织可将丁酸转化为酮体。这种转化与肝切片中观察到的情况相似。生酮活性与肠壁的黏膜而非肌肉相关，并且在结肠中，随着距盲肠 - 结肠交界处距离的增加而降低。2. 回肠、盲肠、近端结肠和远端结肠壁的组织也被证明可将[1-(14)C]丁酸代谢为二氧化碳。3. 酶分析表明，在肝组织和盲肠黏膜中，羟甲基戊二酰辅酶A合酶的活性均比乙酰乙酰辅酶A脱酰酶的活性高十多倍。体外标记实验证实了羟甲基戊二酰辅酶A途径。4. 讨论了丁酸转化为酮体的意义。
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