Price A B, Larson H E, Crow J
Gut. 1979 Jun;20(6):467-75. doi: 10.1136/gut.20.6.467.
The morphology of antibiotic-associated enterocolitis in the hamster is described and compared with human antibiotic-associated pseudomembranous colitis. It is shown to be a caecal disease with proliferative mucosal changes and in this respect unlike the human counterpart. The bacteriology and toxicology, however, are identical. In addition, mucosal changes are described in animals on antibiotics but without established enterocolitis. As a result we suggest that there may be a spectrum of human disease ranging from mild antibiotic-associated diarrhoea to established pseudomembranous colitis. Therefore, despite the morphological variation, the hamster remains a good model for investigating the pathogenesis of pseudomembranous colitis and antibiotic-associated enteropathy in general.
描述了仓鼠抗生素相关性小肠结肠炎的形态，并与人类抗生素相关性假膜性结肠炎进行了比较。结果表明，这是一种盲肠疾病，伴有增生性黏膜改变，在这方面与人类疾病不同。然而，其细菌学和毒理学是相同的。此外，还描述了使用抗生素但未发生确诊小肠结肠炎的动物的黏膜变化。因此，我们认为人类疾病可能存在一个范围，从轻度抗生素相关性腹泻到确诊的假膜性结肠炎。所以，尽管存在形态学差异，但仓鼠总体上仍是研究假膜性结肠炎和抗生素相关性肠病发病机制的良好模型。
