Prévost J M, Peetermans J, Lamy F, Huygelen C
Infect Immun. 1973 Sep;8(3):420-4. doi: 10.1128/iai.8.3.420-424.1973.
A live attenuated influenza virus ("Ann" strain) derived from A/England/878/69 was given intranasally to a group of volunteers, most of whom had already circulating antibodies against H(3)N(2) viruses at the time of inoculation. There was a fourfold or higher increase of circulating hemagglutination-inhibiting antibodies in those volunteers who had relatively low initial titers. The response was lower in those with initially higher serum titers. The pattern of the serum neutralizing antibody response was very similar. The geometric means of the antineuraminidase antibodies were 67 and 118 pre- and postvaccination, respectively. All subjects showed a rise in local neutralizing antibodies in their nasal secretions with geometric means of 4 and 17 pre- and postvaccination, respectively. The levels of local antineuraminidase antibodies also rose in most subjects. In addition to the response to the homologous virus type, the antibody formation to the recent A/England/42/72 was measured in the sera and nasal secretions of some subjects. There was a clearcut response in most of the sera and in all of the secretions examined. The stimulation of circulating lymphocytes was measured in 6 volunteers. All volunteers showed a temporary stimulation. The stimulation index ranged between 2.5 and 28.5.
将源自A/England/878/69的减毒活流感病毒（“Ann”株）经鼻内接种给一组志愿者，其中大多数人在接种时体内已经存在针对H(3)N(2)病毒的循环抗体。初始滴度相对较低的志愿者体内循环血凝抑制抗体增加了四倍或更高。初始血清滴度较高的志愿者反应较低。血清中和抗体反应模式非常相似。抗神经氨酸酶抗体的几何平均值在接种前和接种后分别为67和118。所有受试者鼻分泌物中的局部中和抗体均升高，接种前和接种后的几何平均值分别为4和17。大多数受试者的局部抗神经氨酸酶抗体水平也有所升高。除了对同源病毒型的反应外，还在一些受试者的血清和鼻分泌物中检测了对近期A/England/42/72的抗体形成。在大多数血清和所有检测的分泌物中都有明显的反应。对6名志愿者的循环淋巴细胞刺激情况进行了检测。所有志愿者均出现暂时刺激。刺激指数在2.5至28.5之间。
