Yogev R, Williams T
Antimicrob Agents Chemother. 1979 Jul;16(1):7-8. doi: 10.1128/AAC.16.1.7.
Investigation of two infants suggested that peak ventricular fluid levels of chloramphenicol after intravenous administration were achieved after 3 h. The penetration of chloramphenicol into ventricular fluid may be unpredictable. In one patient, the peak ventricular fluid level was 57.5% of the peak serum level, and it was only 22.5% in the other patient. This observation may explain some of the past treatment failures when chloramphenicol was utilized in patients with gram-negative ventriculitis and meningitis.
对两名婴儿的调查表明，静脉给药后氯霉素在脑室液中的峰值水平在3小时后达到。氯霉素进入脑室液的情况可能无法预测。在一名患者中，脑室液峰值水平为血清峰值水平的57.5%，而在另一名患者中仅为22.5%。这一观察结果可能解释了过去在革兰氏阴性脑室炎和脑膜炎患者中使用氯霉素时的一些治疗失败情况。
