基因选择的高反应和低反应小鼠品系中的狂犬病病毒免疫力。
Rabies virus immunity in genetically selected high- and low-responder lines of mice.
作者信息
Nilsson M R, Sant'anna O A, Siqueira M, Nilsson T T, Gennari M
出版信息
Infect Immun. 1979 Jul;25(1):23-6. doi: 10.1128/iai.25.1.23-26.1979.
Abstract
The antibody responsiveness to and the specific vaccination effect of rabies virus infection were investigated in high- and low-responder lines of mice produced by two-way selective breedings for quantitative production of antibodies to flagellar (H/f and L/f lines) or somatic (H/s and L/s lines) antigens of salmonellae. After specific immunization, both high lines were more resistant to rabies virus infection than were the low lines, and the protector effect was related to the level of antibody produced, as demonstrated by neutralizing serum activity. The present findings confirm the nonspecific genetic modification of the general antibody responsiveness induced in high- and low-responder lines selected for quantitative antibody production.
摘要
通过对沙门氏菌鞭毛（H/f和L/f系）或菌体（H/s和L/s系）抗原抗体定量产生进行双向选择育种培育出的高应答和低应答品系小鼠，研究了其对狂犬病病毒感染的抗体反应性及特异性疫苗接种效果。特异性免疫后，两个高应答品系小鼠比低应答品系小鼠对狂犬病病毒感染更具抵抗力，且保护作用与产生的抗体水平相关，这通过血清中和活性得以证明。目前的研究结果证实了在为抗体定量产生而选择的高应答和低应答品系中诱导的一般抗体反应性的非特异性基因修饰。
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