Frommell G T, Rothenberg R, Wang S, McIntosh K
J Pediatr. 1979 Jul;95(1):28-32. doi: 10.1016/s0022-3476(79)80077-3.
In 340 women, cultured prospectively during their pregnancies, the rate of infection with Chlamydia trachomatis was 8.8%. The women with positive cultures tended to be younger and more often single and black than their counterparts with negative cultures. There were no statistically significant clinical differences between the two groups. Eighteen children born to Chlamydia culture-positive women and 16 born to negative women were followed for nine months to examine the potential effects of maternal infection on infant growth, development, and illness. Eleven of 18 study patients had culture or tear antibody evidence of Chlamydia infection, as opposed to one of the control subjects (P = 0.00093). Eight of these 11 had clinical conjunctivitis, and two of the eight developed pneumonia. Growth retardation and developmental abnormalities were not detected in either group. It is concluded that maternal carriage of C. trachomatis is associated with a high incidence of clinical illness in the offspring.
在340名孕期接受前瞻性培养的女性中，沙眼衣原体感染率为8.8%。培养结果呈阳性的女性往往比培养结果呈阴性的女性更年轻，单身和黑人的比例更高。两组之间在统计学上没有显著的临床差异。对18名沙眼衣原体培养阳性女性所生的孩子和16名培养阴性女性所生的孩子进行了为期9个月的跟踪，以检查母体感染对婴儿生长、发育和疾病的潜在影响。18名研究患者中有11人有沙眼衣原体感染的培养或泪液抗体证据，而对照组中只有1人有（P = 0.00093）。这11人中有8人患有临床结膜炎，其中2人发展为肺炎。两组均未检测到生长发育迟缓及发育异常。结论是，母体携带沙眼衣原体与后代临床疾病的高发病率有关。
