类风湿关节炎患者循环多形核白细胞的定向迁移：血浆中的一种缺陷。
Directed migration of circulating polymorphonuclear leucocytes in patients with rheumatoid arthritis: a defect in the plasma.
作者信息
Walker J R, James D W, Smith M J
出版信息
Ann Rheum Dis. 1979 Jun;38(3):215-8. doi: 10.1136/ard.38.3.215.
Abstract
The migration of peripheral polymorphonuclear leucocytes (PMNs) of patients with rheumatoid arthritis has been studied both in vivo and in vitro. A significant reduction in the accumulation of PMNs in skin chambers in patients with rheumatoid arthritis compared to controls was observed but no defect in cell movement was detected when the isolated PMNs from the patients were exposed to activated control plasma. However, when PMNs from the control group were tested against activated plasma from patients with rheumatoid arthritis there was a significant decrease in their chemotactic response. It is proposed that there is a humoral defect in the plasma of the patients.
摘要
对类风湿性关节炎患者外周多形核白细胞（PMNs）的迁移进行了体内和体外研究。与对照组相比，观察到类风湿性关节炎患者皮肤腔室中PMN的积累显著减少，但当将患者分离出的PMN暴露于活化的对照血浆时，未检测到细胞运动缺陷。然而，当用类风湿性关节炎患者的活化血浆检测对照组的PMN时，其趋化反应显著降低。有人提出，患者血浆中存在体液缺陷。
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