类风湿关节炎中中性粒细胞对补体裂解产物C5a的敏感性降低：与补体分解代谢及疾病程度的关系
Subnormal sensitivity of neutrophils to complement split product C5a in rheumatoid arthritis: relation to complement catabolism and disease extent.
作者信息
Elmgreen J, Hansen T M
出版信息
Ann Rheum Dis. 1985 Aug;44(8):514-8. doi: 10.1136/ard.44.8.514.
Abstract
The capacity of circulating neutrophils for activation by complement was studied in outpatients with classical or definite rheumatoid arthritis during treatment with dextropropoxyphene only. Analysis of dose-response in the Boyden chamber assay of chemotaxis showed that sensitivity to the potent, complement derived anaphylatoxin, C5a, was markedly decreased, especially in those patients with few joints involved. In contrast, peak response to C5a was within the normal range. Increased complement 3c split products in plasma of the patients suggested involvement of complement cascade reactions. Subnormal sensitivity of neutrophils to phlogistic mediators released by complement may tend to limit their recruitment and potentially tissue destroying secretion locally in rheumatoid arthritis.
摘要
仅使用右丙氧芬治疗的典型或确诊类风湿性关节炎门诊患者，对循环中性粒细胞被补体激活的能力进行了研究。在趋化性的博伊登小室试验中对剂量反应的分析表明，对强效补体衍生过敏毒素C5a的敏感性显著降低，尤其是在关节受累较少的患者中。相比之下，对C5a的峰值反应在正常范围内。患者血浆中补体3c裂解产物增加表明补体级联反应参与其中。类风湿性关节炎中，中性粒细胞对补体释放的促炎介质敏感性低于正常水平，这可能会限制其募集以及局部潜在的组织破坏分泌。
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