体外对绵羊红细胞免疫应答中的腹腔巨噬细胞
Peritoneal macrophages in the immune response to SRBC in vitro.
作者信息
Hoffmann M
出版信息
Immunology. 1970 Jun;18(6):791-7.
Abstract
The role of macrophages in the immune response against SRBC in spleen cell suspension cultures obtained from mice was studied. 1. The presence of macrophages increases the number of PFC against SRBC in spleen cell cultures. 2. The ratio peritoneal exudate cells to spleen cells is very critical. Two × 10 peritoneal exudate cells preincubated with sheep red blood cells stimulate 1 × 10 mouse spleen cells to an optimal response. This reaction is suppressed when 2 × 10 peritoneal cells are used. 3. Spleen cell populations which had lost the capability of producing antibodies by elimination of cells adhering to glass yielded a strong immune response upon addition of 2 × 10 peritoneal exudate cells. The significance of macrophages for the induction of the immune response is discussed.
摘要
研究了巨噬细胞在从小鼠获得的脾细胞悬液培养物中针对绵羊红细胞（SRBC）的免疫反应中的作用。1. 巨噬细胞的存在增加了脾细胞培养物中针对SRBC的溶血空斑形成细胞（PFC）的数量。2. 腹腔渗出细胞与脾细胞的比例非常关键。预先与绵羊红细胞孵育的2×10⁶个腹腔渗出细胞可刺激1×10⁶个小鼠脾细胞产生最佳反应。当使用2×10⁷个腹腔细胞时，这种反应受到抑制。3. 通过去除粘附在玻璃上的细胞而失去产生抗体能力的脾细胞群体，在加入2×10⁶个腹腔渗出细胞后产生了强烈的免疫反应。讨论了巨噬细胞对免疫反应诱导的重要性。
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J Immunol. 1965 May;94:765-77.
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