Phillips G B, Runkle R S
Appl Microbiol. 1967 Mar;15(2):378-89. doi: 10.1128/am.15.2.378-389.1967.
Of the large amount of funds spent each year in this country on construction and remodeling of biomedical research facilities, a significant portion is directed to laboratories handling infectious microorganisms. This paper is intended for the scientific administrators, architects, and engineers concerned with the design of new microbiological facilities. It develops and explains the concept of primary and secondary barriers for the containment of microorganisms. The basic objectives of a microbiological research laboratory, (i) protection of the experimenter and staff, (ii) protection of the surrounding community, and (iii) maintenance of experimental validity, are defined. In the design of a new infectious-disease research laboratory, early identification should be made of the five functional zones of the facility and their relation to each other. The following five zones and design criteria applicable to each are discussed: clean and transition, research area, animal holding and research area, laboratory support, engineering support. The magnitude of equipment and design criteria which are necessary to integrate these five zones into an efficient and safe facility are delineated.
在该国每年用于生物医学研究设施建设和改造的大量资金中，有很大一部分用于处理传染性微生物的实验室。本文面向关注新型微生物学设施设计的科学管理人员、建筑师和工程师。它提出并解释了用于微生物控制的一级和二级屏障的概念。定义了微生物研究实验室的基本目标：（i）保护实验人员和工作人员，（ii）保护周边社区，（iii）维持实验有效性。在设计新的传染病研究实验室时，应尽早确定该设施的五个功能区及其相互关系。本文讨论了以下五个区域及其适用的设计标准：清洁和过渡区、研究区、动物饲养和研究区、实验室支持区、工程支持区。阐述了将这五个区域整合为一个高效且安全的设施所需的设备规模和设计标准。
