西咪替丁：对人体胰腺和胆汁功能的影响。
Cimetidine: effect on pancreatic and biliary function in man.
作者信息
Maudgal D P, Lawrence D, Sanderson F M, Northfield T C
出版信息
Br J Clin Pharmacol. 1979 Sep;8(3):229-32. doi: 10.1111/j.1365-2125.1979.tb01006.x.
Abstract
1 Pancreatic and biliary function were studied in eight patients taking oral cimetidine (1.6 g/day for 6 weeks) for endoscopically confirmed active peptic ulcer disease. 2 Postprandial jejunal tryptic activity and bile acid concentration were unchanged during cimetidine given for 1 and 6 weeks. 3 Postprandial gallbladder emptying was also unchanged. 4 Direct examination of postprandial upper jejunal aspirate for deconjugated bile acids was negative in all patients; but the more sensitive [14C]-glycocholate bile acid breath test showed a significant increase in breath 14CO2, indicating increased bacterial deconjugation of bile acids in the gastrointestinal tract.
摘要
- 对8例经内镜证实有活动性消化性溃疡疾病且正在口服西咪替丁（1.6克/天，持续6周）的患者的胰腺和胆汁功能进行了研究。2. 在给予西咪替丁1周和6周期间，餐后空肠胰蛋白酶活性和胆汁酸浓度未发生变化。3. 餐后胆囊排空也未改变。4. 对所有患者餐后上消化道空肠吸出物进行的游离胆汁酸直接检测均为阴性；但更敏感的[14C] - 甘氨胆酸盐胆汁酸呼气试验显示呼气中14CO2显著增加，表明胃肠道中胆汁酸的细菌去结合作用增强。
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本文引用的文献
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