Westley J W, Liu C M, Evans R H, Blount J F
J Antibiot (Tokyo). 1979 Sep;32(9):874-7. doi: 10.7164/antibiotics.32.874.
Fermentation of deposited cultures of Streptomyces conglobatus, known to produce the polyether antibiotic, ionomycin has resulted in the isolation and characterization of a second metabolite, conglobatin (C28H38N2O6). X-Ray analysis revealed a dimeric macrolide dilactone structure for conglobatin, similar to the structures of the mold metabolites vermiculin and pyrenophorin, from which the absolute configuration of conglobatin has been inferred. The dimer consists of two molecules of 7-hydroxy-8-oxazoyl-2,4,6-trimethyl-2-octenoic acid joined by two ester linkages.
已知能产生聚醚抗生素离子霉素的球状链霉菌沉淀培养物发酵后，分离并鉴定出了第二种代谢产物——球孢菌素（C28H38N2O6）。X射线分析揭示了球孢菌素的二聚体大环内酯双内酯结构，类似于霉菌代谢产物蠕霉素和黑麦角菌素的结构，据此推断出了球孢菌素的绝对构型。该二聚体由两个7-羟基-8-恶唑基-2,4,6-三甲基-2-辛烯酸分子通过两个酯键连接而成。
