Deknudt G, Gerber G B
Mutat Res. 1979 Oct;68(2):163-8. doi: 10.1016/0165-1218(79)90144-7.
Mice kept on a normal (1.1% calcium) or low-calcium (0.03%) diet were exposed for one month to zinc chloride (0.5% Zn), lead acetate (0.5% Pb) or cadmium chloride (0.06% Cd) or to a mixture of these salts at half the above concentrations. These concentrations, given in a poor calcium diet, represent an LD 50/30 days. After the mice were killed bone-marrow cells were assayed for chromosomal aberrations, and serum calcium was determined. Chromosomal aberrations were detected in the mice maintained on a low-calcium diet and exposed to lead, zinc or a mixture of lead, zinc and cadmium. The possible mechanism for the synergistic action on genetic effects of the lack of calcium and intoxication by heavy metals are discussed, and it is recommended that routine attention be given to the state of calcium metabolism in heavy-metal intoxication.
将食用正常（1.1%钙）或低钙（0.03%钙）饮食的小鼠暴露于氯化锌（0.5%锌）、醋酸铅（0.5%铅）或氯化镉（0.06%镉）中一个月，或暴露于上述盐类浓度减半的混合物中一个月。在低钙饮食中，这些浓度代表30天半数致死剂量（LD50）。处死小鼠后，检测骨髓细胞的染色体畸变情况，并测定血清钙含量。在食用低钙饮食并暴露于铅、锌或铅、锌、镉混合物的小鼠中检测到了染色体畸变。讨论了钙缺乏与重金属中毒对遗传效应协同作用的可能机制，并建议在重金属中毒时常规关注钙代谢状况。
