小麦胚苯丙氨酸转移核糖核酸的一级结构
Primary structure of wheat germ phenylalanine transfer RNA.
作者信息
Dudock B S, Katz G, Taylor E K, Holley R W
出版信息
Proc Natl Acad Sci U S A. 1969 Mar;62(3):941-5. doi: 10.1073/pnas.62.3.941.
Abstract
The complete nucleotide sequence of wheat germ phenylalanine transfer RNA (tRNA(Phe)) is presented. This RNA, which is an acceptable substrate for yeast phenylalanine tRNA synthetase, has a structure very similar to that of yeast tRNA(Phe). Only 16 of the 76 nucleotides are different, and all but two of the nucleotide changes are located in regions that are doublestranded in the cloverleaf model. The two changes in single-stranded regions involve minor modifications of the same nucleotide. The dihydrouridine loop and its supporting stem are completely free of nucleotide changes.
摘要
本文给出了小麦胚芽苯丙氨酸转移核糖核酸（tRNA(Phe)）的完整核苷酸序列。这种RNA是酵母苯丙氨酸tRNA合成酶的合适底物，其结构与酵母tRNA(Phe)非常相似。76个核苷酸中只有16个不同，除两个核苷酸变化外，其余所有核苷酸变化都位于三叶草模型中的双链区域。单链区域的两个变化涉及同一核苷酸的微小修饰。二氢尿嘧啶环及其支撑茎完全没有核苷酸变化。
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