新型β-内酰胺抗生素LY127935对变形杆菌、克雷伯菌、沙雷菌和假单胞菌的作用
LY127935, a new beta-lactam antibiotic, versus Proteus, Klebsiella, Serratia, and Pseudomonas.
作者信息
Flournoy D J, Perryman F A
出版信息
Antimicrob Agents Chemother. 1979 Nov;16(5):641-3. doi: 10.1128/AAC.16.5.641.
Abstract
One hundred eight clinical isolates of Proteus, Klebsiella, Serratia, and Pseudomonas spp. were tested in vitro against LY127935, cefamandole, cefoxitin, ticarcillin, carbenicillin, gentamicin, tobramycin, and amikacin by broth microdilution. The activities of LY127935 were greater than or equal to those of the other antimicrobial agents against Proteus vulgaris, Klebsiella pneumoniae, and Serratia marcescens. Inhibitions were greatest, however, for ticarcillin and carbenicillin versus Proteus morganii and gentamicin versus Pseudomonas aeruginosa.
摘要
采用肉汤微量稀释法，对108株变形杆菌属、克雷伯菌属、沙雷菌属和假单胞菌属的临床分离菌株进行了体外药敏试验，检测其对LY127935、头孢孟多、头孢西丁、替卡西林、羧苄西林、庆大霉素、妥布霉素和阿米卡星的敏感性。LY127935对普通变形杆菌、肺炎克雷伯菌和粘质沙雷菌的抗菌活性大于或等于其他抗菌药物。然而，替卡西林和羧苄西林对摩根氏变形杆菌的抑制作用最强，庆大霉素对铜绿假单胞菌的抑制作用最强。
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LY127935, a new beta-lactam antibiotic, versus Proteus, Klebsiella, Serratia, and Pseudomonas.新型β-内酰胺抗生素LY127935对变形杆菌、克雷伯菌、沙雷菌和假单胞菌的作用
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本文引用的文献
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Antibiotic susceptibility testing by a standardized single disk method.采用标准化单纸片法进行抗生素敏感性试验。
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Comparison of in vitro antimicrobial activity of cefamandole and cefazolin with cephalothin against over 8,000 clinical bacterial isolates.头孢孟多和头孢唑林与头孢噻吩对8000多株临床分离细菌的体外抗菌活性比较。
Antimicrob Agents Chemother. 1976 Jun;9(6):1066-9. doi: 10.1128/AAC.9.6.1066.
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Comparative in vitro activity of newer cephalosporins against anaerobic bacteria.新型头孢菌素对厌氧菌的体外比较活性
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Comparison between agar and broth minimum inhibitory concentrations of cefamandole, Cefoxitin, and cefuroxime.头孢孟多、头孢西丁和头孢呋辛在琼脂和肉汤中的最低抑菌浓度比较。
Antimicrob Agents Chemother. 1979 Apr;15(4):572-9. doi: 10.1128/AAC.15.4.572.
6
Variation in response of Pseudomonas aeruginosa to combinations of gentamicin and carbenicillin.铜绿假单胞菌对庆大霉素和羧苄青霉素联合用药反应的差异
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