鼻咽分泌物中的呼吸道合胞病毒中和活性
Respiratory syncytial virus neutralizing activity in nasopharyngeal secretions.
作者信息
Scott R, Gardner P S
出版信息
J Hyg (Lond). 1970 Dec;68(4):581-8. doi: 10.1017/s0022172400042510.
Abstract
Nasopharyngeal secretions were taken during the acute phase of illness from 30 children admitted to hospital with lower respiratory tract infections. The presence of neutralizing activity in secretions taken at the onset of illness was demonstrated in 11 out of 15 patients (73%) with bronchiolitis caused by R.S. virus, as compared with 4 out of 9 patients (44%) with R.S. virus infections other than bronchiolitis, and 1 out of 6 without R.S. virus infection. Second secretions were taken 7 days later from 10 of the children with R.S. virus infection. Eight of these paired secretions showed an increase of neutralizing activity against R.S. virus. It is suggested that the neutralizing activity, found in secretions taken at the onset of illness, may be a result of previous infection with R.S. virus.
摘要
在疾病急性期，从30名因下呼吸道感染入院的儿童中采集了鼻咽分泌物。在15例由呼吸道合胞病毒（R.S.病毒）引起的细支气管炎患者中，有11例（73%）在发病时采集的分泌物中显示出中和活性，相比之下，9例非细支气管炎的R.S.病毒感染患者中有4例（44%），6例无R.S.病毒感染的患者中有1例。7天后，从10名感染R.S.病毒的儿童中采集了第二次分泌物。这些配对分泌物中有8例显示出针对R.S.病毒的中和活性增加。有人认为，在发病时采集的分泌物中发现的中和活性可能是先前感染R.S.病毒的结果。
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