单纯疱疹病毒粒子中精胺和亚精胺的区室化
Compartmentalization of spermine and spermidine in the herpes simplex virion.
作者信息
Gibson W, Roizman B
出版信息
Proc Natl Acad Sci U S A. 1971 Nov;68(11):2818-21. doi: 10.1073/pnas.68.11.2818.
Abstract
Enveloped particles of herpes simplex virus produced in human cells in culture contained spermidine and spermine, in a molar ratio of 1.6 +/- 0.2. The spermine present within the nucleocapsid is sufficient to neutralize at least 40% of the viral DNA. Disruption of the envelope with nonionic detergent and urea resulted in the selective loss of spermidine. Exogenous ornithine can function as a precursor to host and viral polyamines only before infection.
摘要
在培养的人细胞中产生的单纯疱疹病毒包膜颗粒含有亚精胺和精胺，摩尔比为1.6±0.2。核衣壳内的精胺足以中和至少40%的病毒DNA。用非离子去污剂和尿素破坏包膜导致亚精胺选择性丢失。外源性鸟氨酸仅在感染前可作为宿主和病毒多胺的前体。
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