被动抗体对狂犬病疫苗诱导的主动免疫的抑制作用。
Inhibitory effect of passive antibody on active immunity induced against rabies by vaccination.
作者信息
Wiktor T J, Lerner R A, Koprowski H
出版信息
Bull World Health Organ. 1971;45(6):747-53.
Abstract
The administration of rabies-immune serum in addition to regular vaccination has been recommended as routine treatment in man after severe exposure to rabies virus. The inhibitory effect of passive antibody on active immunity induced against rabies by vaccination was investigated in rabbits. It was demonstrated that a dose of rabies-immune serum could completely block the neutralizing antibody response engendered by a very potent rabies vaccine. The inhibitory effect could be partially overcome if the number of vaccine doses was increased, if vaccination was started 15 days after serum administration, or if immune serum was given 12-24 hours after vaccination. Even under these circumstances, the antibody level was lower than that observed after administration of vaccine alone. Both 19S and 7S antibody exerted similar effects.
摘要
除常规疫苗接种外，建议对严重暴露于狂犬病病毒的人注射狂犬病免疫血清作为常规治疗方法。研究人员在兔子身上研究了被动抗体对狂犬病疫苗诱导的主动免疫的抑制作用。结果表明，一定剂量的狂犬病免疫血清可完全阻断一种高效狂犬病疫苗产生的中和抗体反应。如果增加疫苗剂量、在注射血清15天后开始接种疫苗或在接种疫苗12 - 24小时后注射免疫血清，这种抑制作用可部分克服。即便在这些情况下，抗体水平仍低于仅接种疫苗后的水平。19S和7S抗体均产生了类似效果。
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