Giles G R, Humphries C, Mason M C, Clark C G
Gut. 1969 Oct;10(10):852-6. doi: 10.1136/gut.10.10.852.
In 16 normal subjects the pressure characteristics of the cardiac sphincter have been examined. The effect of perfusing the gastric aspect of the sphincter mucosa has been studied by comparing the effects of saline with those of solutions where pH ranged from 1.0 to 8.0. Acid perfusion produced an increase in sphincteric pressure, particularly at pH 3.0. This suggests that a physiological mechanism exists which can increase the barrier pressure to gastrooesophageal reflux during periods of active secretion of the stomach, as occurs in digestion.
对16名正常受试者的贲门括约肌压力特征进行了检查。通过比较生理盐水与pH值范围为1.0至8.0的溶液对括约肌黏膜胃侧灌注的效果，研究了灌注的影响。酸灌注导致括约肌压力增加，尤其是在pH值为3.0时。这表明存在一种生理机制，在胃的活跃分泌期（如消化过程中），该机制可增加对胃食管反流的屏障压力。
