含核糖核酸的大肠杆菌噬菌体的血清学相关性。
Serological relatedness of the ribonucleic acid-containing coliphages.
作者信息
Krueger R G
出版信息
J Virol. 1969 Nov;4(5):567-73. doi: 10.1128/JVI.4.5.567-573.1969.
The serological relationship of the ribonucleic acid (RNA)-containing coliphages MS-2, M-12, R-17, f(2), beta, fr, f(4), and Qbeta was determined. Antisera against MS-2, R-17, f(2), fr, and Qbeta neutralized the infectivity of all of these RNA phages to varying degrees. Although each phage was serologically distinct, the antisera cross-reacted with certain phages to approximately the same degree, indicating the antigenic relationship of the coat proteins of these phages. Adsorption of anti-MS-2 sera with varying concentrations of all of the phages demonstrated that these viruses contain similar yet unique antigenic determinants. It is suggested that these RNA phages are mutants of two related phages rather than of the same phage.
测定了含核糖核酸（RNA）的大肠杆菌噬菌体MS-2、M-12、R-17、f(2)、β、fr、f(4)和Qβ的血清学关系。抗MS-2、R-17、f(2)、fr和Qβ的抗血清在不同程度上中和了所有这些RNA噬菌体的感染性。虽然每种噬菌体在血清学上都是独特的，但抗血清与某些噬菌体的交叉反应程度大致相同，这表明这些噬菌体的外壳蛋白存在抗原关系。用不同浓度的所有噬菌体吸附抗MS-2血清表明，这些病毒含有相似但独特的抗原决定簇。有人提出，这些RNA噬菌体是两种相关噬菌体的突变体，而不是同一噬菌体的突变体。
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