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一些长链脂肪酸N-取代酰胺的抗菌活性。

Antimicrobial activity of some N-substituted amides of long-chain fatty acids.

作者信息

Novak A F, Solar J M, Mod R R, Magne F C, Skau E L

出版信息

Appl Microbiol. 1969 Dec;18(6):1050-6. doi: 10.1128/am.18.6.1050-1056.1969.

DOI:10.1128/am.18.6.1050-1056.1969
PMID:5370658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC378191/
Abstract

Seventy-three N,N-disubstituted amides of long-chain, principally C(18), fatty acids were screened for antimicrobial activity against bacteria, yeasts, and molds. Amides containing an epoxy group exhibit a broad spectrum of antimicrobial activity which is further enhanced by unsaturation. Mono-unsaturation alone does not contribute a broad level of activity to the N,N-disubstituted amides of the C(18) fatty acids.

摘要

对73种主要为C(18)长链脂肪酸的N,N-二取代酰胺进行了抗细菌、酵母和霉菌的抗菌活性筛选。含有环氧基的酰胺表现出广谱抗菌活性，这种活性会因不饱和键而进一步增强。仅单不饱和键不会为C(18)脂肪酸的N,N-二取代酰胺带来广泛的活性水平。

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本文引用的文献

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Science. 1959 Aug 21;130(3373):452-3. doi: 10.1126/science.130.3373.452.
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J Bacteriol. 1959 May;77(5):573-80. doi: 10.1128/jb.77.5.573-580.1959.
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Bacteriostatic, fungistatic, and algistatic activity of fatty nitrogen compounds.脂肪族含氮化合物的抑菌、抑真菌和抑藻活性。
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