大Y染色体（Yq+）与流产风险增加
Large Y chromosome (Yq+) and increased risk of abortion.
作者信息
Nielsen J
出版信息
Clin Genet. 1978 May;13(5):415-6. doi: 10.1111/j.1399-0004.1978.tb04140.x.
Abstract
Previous reports have indicated an association between Yq+ in the family and increased risk of abortion. In a chromosome investigations of 11,148 consecutively newborn children, we found 58 boys with a large Y chromosome (Y/F equal to or greater than 1.00). The mothers of these boys had 22% abortions, compared with 13% among 4,895 mothers of children with normal karyotypes and without Yq+ (P less than 0.001).
摘要
先前的报告表明，家族中的Yq+与流产风险增加之间存在关联。在对11148名连续出生的新生儿进行的染色体调查中，我们发现58名男孩的Y染色体较大（Y/F等于或大于1.00）。这些男孩的母亲中有22%发生了流产，而在4895名核型正常且无Yq+的儿童的母亲中，这一比例为13%（P<0.001）。
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