Pietrek J, Preece M A, Windo J, O'Riordan J L, Dunnigan M G, McIntosh W B, Ford J A
Lancet. 1976 May 29;1(7970):1145-8. doi: 10.1016/s0140-6736(76)91539-7.
Asian families living in Glasgow were studied between December, 1973, and June, 1974. One group of families served as a control; their mean serum-25-hydroxy-vitamin-D (25-hydroxy-cholecalciferol and 25-hydroxyergocalciferol) remained low, being 5-1 +/- 0-8 (S.E.M.) ng/ml at the end of the study. A second group was given 3000 units of vitamin D2 in a capsule weekly; this raised the mean concentration of 25-hydroxy-vitamin-D to 18-1 +/- 2-9 ng/ml. The variable effectiveness of this supplement was attributable to some subjects not taking the capsules regularly. The third group of families was provided with chupatty flour fortified with vitamin D(6000 units per kg). This increased mean serum-25-hydroxy-vitamin-D very uniformly to a mean value of 19-5 +/- 1-2 ng/ml. It is concluded that vitamin-D deficiency in Asian immigrants could be substantially reduced by fortification of chupatty flour with vitamin D.
1973年12月至1974年6月期间，对居住在格拉斯哥的亚裔家庭进行了研究。一组家庭作为对照组；他们的血清25-羟基维生素D（25-羟基胆钙化醇和25-羟基麦角钙化醇）平均水平仍然较低，研究结束时为5.1±0.8（标准误）纳克/毫升。第二组家庭每周服用一粒含3000单位维生素D2的胶囊；这使25-羟基维生素D的平均浓度提高到18.1±2.9纳克/毫升。这种补充剂效果不一，原因是一些受试者没有定期服用胶囊。第三组家庭食用添加了维生素D（每千克6000单位）的薄饼粉。这使血清25-羟基维生素D的平均水平非常一致地提高到19.5±1.2纳克/毫升。结论是，通过在薄饼粉中添加维生素D，可以大幅减少亚裔移民中的维生素D缺乏情况。
