Jordan G W, Hoeprich P D
Antimicrob Agents Chemother. 1977 Jan;11(1):7-12. doi: 10.1128/AAC.11.1.7.
Because of the need for non-beta-lactam antimicrobics with antistaphylococcal activity, 14 antimicrobics (3 penicillinase-resistant penicillins, 7 aminocyclitols [5 new], 2 macrolides [1 new], clindamycin, and a new polysaccharide, everninomicin) were tested in vitro for activity against 22 penicillin-susceptible, 51 penicillin-resistant, and 47 methicillin-resistant strains of Staphylococcus aureus. Gentamicin, tobramycin, sisomicin, and verdamicin inhibited almost all strains at concentrations less than 1 mug/ml. The methicillin-resistant strains were as susceptible as other strains to the aminocyclitols and everninomicin. In contrast, many of the methicillin-resistant strains were also resistant to erythromycin, rosamicin, and clindamycin at attainable serum concentrations. The use of the bacterial synthetic amino acid medium, in comparison with Mueller-Hinton broth, resulted in an increase in the observed resistance of methicillin-resistant strains to the penicillinase-resistant semisynthetic penicillins.
由于需要具有抗葡萄球菌活性的非β-内酰胺类抗菌药物，对14种抗菌药物（3种耐青霉素酶青霉素、7种氨基环醇类药物[5种为新药物]、2种大环内酯类药物[1种为新药物]、克林霉素和一种新的多糖类药物，埃维诺霉素）进行了体外试验，以检测它们对22株青霉素敏感、51株青霉素耐药和47株耐甲氧西林金黄色葡萄球菌菌株的活性。庆大霉素、妥布霉素、西索米星和紫苏霉素在浓度低于1微克/毫升时能抑制几乎所有菌株。耐甲氧西林菌株对氨基环醇类药物和埃维诺霉素的敏感性与其他菌株相同。相比之下，许多耐甲氧西林菌株在可达到的血清浓度下对红霉素、罗沙米星和克林霉素也具有耐药性。与穆勒-欣顿肉汤相比，使用细菌合成氨基酸培养基导致耐甲氧西林菌株对耐青霉素酶半合成青霉素的耐药性增加。
