班图族原发性肝细胞癌患者的乙肝表面抗原和抗体
Hepatitis-B surface antigen and antibody in Bantu patients with primary hepatocellular cancer.
作者信息
Macnab G M, Urbanowicz J M, Geddes E W, Kew M C
出版信息
Br J Cancer. 1976 May;33(5):544-8. doi: 10.1038/bjc.1976.86.
Hepatitis-B surface antigen (HBsAg) was found in the serum of 58 of 158 (36-4%) southern African Bantu patients with primary hepatocellular cancer by counter immunoelectrophoresis and in 94 (59-5%) by radioimmunoassay (RIA). The prevalence of this antigen in the general Bantu population using these methods was 7% and 9% respectively. Antibody against HBsAg was detected in 11-6% of the patients by passive haemagglutination (PH) and 13-4% by RIA, and in 33-4% (by PH) of a control population. Antibody sub-types were predominantly "adw" (69-2%) with a lesser frequency of "ayw" (23%), while 7-8% were indeterminate. The corresponding figures in the controls were 80-4, 8-4 and 11-2%. HBsAg was more common in younger patients. No relationship could be demonstrated between hepatitis-B antigenaemia and the presence of alpha-foetoprotein in high concentration, although there were far fewer patients in the alpha-foetoprotein-negative group.
通过对流免疫电泳法在158例南非班图族原发性肝细胞癌患者中的58例（36.4%）血清中检测到乙肝表面抗原（HBsAg），通过放射免疫测定法（RIA）在94例（59.5%）患者血清中检测到该抗原。使用这些方法，该抗原在班图族普通人群中的流行率分别为7%和9%。通过被动血凝试验（PH）在11.6%的患者中检测到抗HBsAg抗体，通过RIA在13.4%的患者中检测到该抗体，在对照人群中通过PH检测到该抗体的比例为33.4%。抗体亚型主要为“adw”（69.2%），“ayw”频率较低（23%），而7.8%为不确定型。对照组中的相应数字分别为80.4%、8.4%和11.2%。HBsAg在年轻患者中更为常见。虽然甲胎蛋白阴性组的患者少得多，但乙肝抗原血症与高浓度甲胎蛋白的存在之间未显示出相关性。
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