Relationship of human rhinovirus strain 2 and poliovirus as indicated by comparison of the polymerase gene regions.

cDNA clones representing the 3'-terminal region of the human rhinovirus strain 2 genome have been obtained. The sequence of 1425 nucleotides adjacent to the poly(A) tract is presented and contains an open reading frame of 1383 nucleotides. The derived amino acid sequence corresponding to the putative RNA polymerase-coding region is compared to those of poliovirus type 1 (Mahoney) and foot-and-mouth disease virus A12. A high degree of homology between human rhinovirus strain 2 and poliovirus type 1 (Mahoney) was found within the coding sequence but not within the 3'-untranslated region.