McSweeney M B, Small W C, Cerny V, Sewell W, Powell R W, Goldstein J H
Radiology. 1984 Dec;153(3):741-4. doi: 10.1148/radiology.153.3.6093191.
The ability of magnetic resonance imaging (MR) to demonstrate breast carcinoma depends upon significantly different relaxation times in benign and malignant tissues. The authors conducted an in vitro study of transverse relaxation times (T2) of 393 breast tissue samples in order to establish a range of values for normal tissue, benign lesions, and carcinoma. All T2 values were multiexponential. Benign lesions were readily distinguished from both invasive and noninvasive carcinoma in samples containing fat or a mixture of fat and fibrous tissue; however, in purely fibrous samples there was some overlap of T2 values in benign and malignant tissues. Although the data acquisition and analysis requirements involved in this in vitro study exceed the capabilities of present whole-body MR imagers, the added understanding gained through efforts of this type may aid both interpretation of current images and future developments.
磁共振成像（MR）显示乳腺癌的能力取决于良性和恶性组织中显著不同的弛豫时间。作者对393个乳腺组织样本的横向弛豫时间（T2）进行了一项体外研究，以确定正常组织、良性病变和癌的一系列数值。所有T2值均为多指数形式。在含有脂肪或脂肪与纤维组织混合物的样本中，良性病变很容易与浸润性癌和非浸润性癌区分开来；然而，在纯纤维样本中，良性和恶性组织的T2值存在一些重叠。尽管这项体外研究中涉及的数据采集和分析要求超出了目前全身MR成像仪的能力，但通过这类努力获得的更多认识可能有助于当前图像的解读和未来的发展。
