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卡波西肉瘤:肿瘤标本中存在疱疹型病毒颗粒。

Kaposi's sarcoma: presence of herpes-type virus particles in a tumor specimen.

作者信息

Walter P R, Philippe E, Nguemby-Mbina C, Chamlian A

出版信息

Hum Pathol. 1984 Dec;15(12):1145-6. doi: 10.1016/s0046-8177(84)80309-3.

DOI:10.1016/s0046-8177(84)80309-3
PMID:6094332
Abstract

Three Kaposi's sarcoma biopsy specimens obtained from three African patients with typical nodular cutaneous tumors were investigated morphologically for cellular modifications suggestive of a viral origin. In one case a Kaposi's sarcoma cell of the endothelial type contained a few intranuclear herpes-type viral inclusions. The present findings complement previous reports of herpes-type viral particles in Kaposi's sarcoma cultured cell lines and suggest that, at least under certain conditions, Kaposi's sarcoma cells enter a virus-producing phase.

摘要

对从三名患有典型结节性皮肤肿瘤的非洲患者身上获取的三份卡波西肉瘤活检标本进行了形态学研究,以寻找提示病毒起源的细胞变化。在一例中,内皮型卡波西肉瘤细胞含有一些核内疱疹型病毒包涵体。本研究结果补充了先前关于卡波西肉瘤培养细胞系中疱疹型病毒颗粒的报道,并表明,至少在某些情况下,卡波西肉瘤细胞进入了病毒产生阶段。

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Kaposi's sarcoma: presence of herpes-type virus particles in a tumor specimen.卡波西肉瘤:肿瘤标本中存在疱疹型病毒颗粒。
Hum Pathol. 1984 Dec;15(12):1145-6. doi: 10.1016/s0046-8177(84)80309-3.
2
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Ann Pathol. 1984 Jan-Mar;4(1):19-25.
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The conundrum of causality in tumor virology: the cases of KSHV and MCV.肿瘤病毒学中的因果关系难题:卡波西肉瘤相关疱疹病毒和 Merkel 细胞多瘤病毒的案例
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Why do viruses cause cancer? Highlights of the first century of human tumour virology.
病毒为何会致癌?人类肿瘤病毒学的首个百年亮点。
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Human herpesvirus 8--a novel human pathogen.人类疱疹病毒8型——一种新型人类病原体。
Virol J. 2005 Sep 2;2:78. doi: 10.1186/1743-422X-2-78.
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Long-term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8.人疱疹病毒8对真皮微血管内皮细胞的长期感染与转化
J Virol. 1999 Aug;73(8):6892-902. doi: 10.1128/JVI.73.8.6892-6902.1999.
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Mol Pathol. 1997 Feb;50(1):4-8. doi: 10.1136/mp.50.1.4.
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