Nazzaro-Porro M, Passi S, Zina G, Bernengo A, Breathnach A, Gallagher S, Morpurgo G
Lancet. 1980 May 24;1(8178):1109-11. doi: 10.1016/s0140-6736(80)91555-x.
In 23 patients with malignant melanoma, including some with metastases and terminal patients, topical and oral (10--15 g daily) azelaic acid given for 1--12 weeks before surgical excision of the lesions was followed by arrest and subsequent regression of the advancing edge of lesions, reduction in size and flattening of nodular areas, and progressive lightening of pigmentation. Histological and ultrastructural effects included: degeneration and disappearance of malignant epidermal and dermal melanocytes with reduction of junctional activity; epidermal proliferation and return towards normal organisation; reappearance of papillary dermis, pilosebaceous units, and sweat glands; separation of dermal melanoma tumour masses into smaller collections of cells by regenerating connective tissue; and increase in number of dermal mast cells, macrophages, and round cells. These preliminary results indicate a direct cytotoxic effect of azelaic acid on melanocytes of human melanoma.
在23例恶性黑色素瘤患者中，包括一些有转移灶的患者和晚期患者，在手术切除病灶前1至12周给予外用和口服（每日10 - 15克）壬二酸，随后病灶的进展边缘停滞并逐渐消退，结节区域尺寸减小且变平，色素沉着逐渐减轻。组织学和超微结构效应包括：恶性表皮和真皮黑素细胞变性和消失，交界活性降低；表皮增生并恢复正常结构；乳头真皮、毛囊皮脂腺单位和汗腺重新出现；再生结缔组织将真皮黑色素瘤肿瘤块分隔成较小的细胞团；真皮肥大细胞、巨噬细胞和圆形细胞数量增加。这些初步结果表明壬二酸对人黑色素瘤的黑素细胞有直接细胞毒性作用。
