Bayley A C
Lancet. 1984 Jun 16;1(8390):1318-20. doi: 10.1016/s0140-6736(84)91818-x.
From 1975 to 1982 between 8 and 12 new cases of Kaposi's sarcoma (KS) were seen each year in Lusaka, Zambia, and the clinical presentation and tumour behaviour conformed to descriptions of endemic KS from Uganda and Kenya. 23 patients presented with KS in 1983. 10 men, mean age 41, presented with typical symptoms and signs (nodules or plaques on oedematous limbs, with florid tumours or woody infiltration) and all 10 patients responded promptly to actinomycin D and vincristine. 13 patients (10 men and 3 women), mean age 27, presented with unusual symptoms and signs, including generalised symmetrical lymphadenopathy, oral or gastrointestinal lesions, respiratory distress, gross weight loss, and absence of nodules or plaques on the limbs. 8 of 13 patients with atypical KS failed to maintain an initial response to chemotherapy and died before the end of 1983, but there were no deaths amongst patients with endemic disease.
1975年至1982年期间，赞比亚卢萨卡每年有8至12例新的卡波西肉瘤（KS）病例，其临床表现和肿瘤行为与来自乌干达和肯尼亚的地方性KS描述相符。1983年有23例患者出现KS。10名男性，平均年龄41岁，表现出典型症状和体征（水肿肢体上有结节或斑块，伴有茂盛的肿瘤或木质样浸润），所有10名患者对放线菌素D和长春新碱反应迅速。13名患者（10名男性和3名女性），平均年龄27岁，表现出不寻常的症状和体征，包括全身对称性淋巴结肿大、口腔或胃肠道病变、呼吸窘迫、体重显著减轻以及肢体上无结节或斑块。13例非典型KS患者中有8例未能维持对化疗的初始反应，并于1983年底前死亡，但地方性疾病患者中无死亡病例。
