人淋巴细胞对甲型流感病毒/苏联株（H1N1）感染的细胞介导免疫反应。
Cell-mediated immune response of human lymphocytes to influenza A/USSR (H1N1) virus infection.
作者信息
Lazar A, Wright P F
出版信息
Infect Immun. 1980 Mar;27(3):867-71. doi: 10.1128/iai.27.3.867-871.1980.
Cell-mediated immunity to influenza A/USSR (H1N1) virus was assessed by measuring transformation response and interferon production by Ficoll-Hypaque-purified peripheral blood lymphocytes from children and adults. Lymphocyte transformation was found to be related to the individual's previous experience with H1N1 influenza virus. Lymphocyte cultures, obtained from adults who had their last contact with the H1N1 virus over 20 years ago, were able to transform when incubated with H1N1 influenza antigens. This response suggests that influenza virus can induced long-term cell-mediated immunity for periods of at least 20 years. Interferon produced by stimulated lymphocytes was found to be unrelated to previous contact with influenza H1N1 virus; seronegative as well as seropositive individuals were capable of producing interferon in response to viral antigens. The interferon produced was type I.
通过检测儿童和成人经Ficoll-泛影葡胺纯化的外周血淋巴细胞的转化反应和干扰素生成情况，评估了针对甲型流感病毒/苏联株（H1N1）的细胞介导免疫。发现淋巴细胞转化与个体既往感染H1N1流感病毒的经历有关。从20多年前最后一次接触H1N1病毒的成年人中获取的淋巴细胞培养物，在与H1N1流感抗原一起孵育时能够发生转化。这种反应表明，流感病毒可诱导至少20年的长期细胞介导免疫。发现受刺激淋巴细胞产生的干扰素与既往接触H1N1流感病毒无关；血清阴性和血清阳性个体均能够针对病毒抗原产生干扰素。所产生的干扰素为I型。
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