再次接种牛痘疫苗后淋巴细胞对牛痘抗原的干扰素反应选择性增加。
Selective increase in lymphocyte interferon response to vaccinia antigen after revaccination.
作者信息
Epstein L B, Stevens D A, Merigan T C
出版信息
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2632-6. doi: 10.1073/pnas.69.9.2632.
Abstract
Viral antigen prepared by heat inactivation of vaccinia virus stimulated production of interferon in association with transformation of sensitized human lymphocytes in vitro. Involvement of a macrophage-lymphocyte interaction in production of interferon stimulated by viral antigen was found in which macrophage greatly augmented the amount of interferon produced by lymphocytes. Reimmunization with live vaccinia virus resulted in a selective increase in the ability of lymphocytes to produce interferon in the presence of viral antigen 4-7 weeks later without a corresponding increase in the degree of already significant lymphocyte transformation. There was no correlation between the extent of lymphocyte transformation and the amount of interferon produced. The augmented interferon response after reimmunization described in this study may be a significant component of the protective effect of immunization with vaccinia against disease occurring after exposure to small-pox.
摘要
通过痘苗病毒热灭活制备的病毒抗原，在体外与致敏的人淋巴细胞转化相关联地刺激了干扰素的产生。发现病毒抗原刺激产生干扰素过程中存在巨噬细胞 - 淋巴细胞相互作用，其中巨噬细胞极大地增加了淋巴细胞产生的干扰素量。用活痘苗病毒再次免疫4 - 7周后，淋巴细胞在病毒抗原存在下产生干扰素的能力选择性增加，而已经显著的淋巴细胞转化程度没有相应增加。淋巴细胞转化程度与产生的干扰素量之间没有相关性。本研究中描述的再次免疫后增强的干扰素反应可能是痘苗免疫对接触天花后发生疾病的保护作用的重要组成部分。
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