传代后期的SC-1细胞对N型和B型嗜性病毒具有抗性，但对NB型嗜性病毒敏感。
Late-passage SC-1 cells resistant to N- and B-tropic viruses but sensitive to NB-tropic viruses.
作者信息
Pincus T
出版信息
J Virol. 1980 Jun;34(3):711-5. doi: 10.1128/JVI.34.3.711-715.1980.
Abstract
A late-passage derivative of SC-1 cells with stable relative resistance to N- and B-tropic viruses but with retained sensitivity to NB-tropic viruses has been identified. Dual resistance was seen with the XC plaque assay, as well as reverse transcriptase assay and radioimmunoassay for viral p30. Evidence was found for resistance in clonal derivatives. These findings suggest a possible instability in determinants of cellular resistance to endogenous retroviruses and may be useful in further analysis of resistance to retrovirus infection.
摘要
已鉴定出一种SC-1细胞的传代后期衍生物，它对N型和B型嗜性病毒具有稳定的相对抗性，但对NB型嗜性病毒仍保持敏感性。通过XC蚀斑试验、逆转录酶试验以及针对病毒p30的放射免疫测定，均观察到了双重抗性。在克隆衍生物中也发现了抗性证据。这些发现表明细胞对内源性逆转录病毒抗性决定因素可能存在不稳定性，并且可能有助于进一步分析对逆转录病毒感染的抗性。
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