人成纤维细胞干扰素cDNA的核苷酸序列。

The nucleotide sequence of human fibroblast interferon cDNA.

作者信息

Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M

出版信息

Gene. 1980 Jun;10(1):11-5. doi: 10.1016/0378-1119(80)90138-9.

Abstract

DNA synthesized by in vitro reverse transcription of the interferon mRNA has been cloned and amplified as recombinant DNA, TpIF319-13 (Taniguchi et al., 1979). The nucleotide sequence of this IF cDNA which consists of 770 bp (excluding the A:T tails) has been determined. The data reported predict the hitherto unknown amino acid sequence of human fibroblast interferon and its putative signal peptide.

摘要

通过干扰素信使核糖核酸的体外逆转录合成的DNA已被克隆并作为重组DNA（TpIF319 - 13，谷口等人，1979年）进行扩增。已确定了这个由770个碱基对（不包括A:T尾）组成的干扰素互补DNA的核苷酸序列。所报告的数据预测了迄今未知的人成纤维细胞干扰素的氨基酸序列及其假定的信号肽。