Démant P, Iványi D
Nature. 1981 Mar 12;290(5802):146-9. doi: 10.1038/290146a0.
The K and D regions of the H-2 gene complex are highly polymorphic and control cell-surface structures involved in the H-2 restriction of cytotoxic T lymphocytes. Originally it was assumed that each of these regions controlled only one type of antigenic molecule, H-2K and H-2D, respectively. The finding that the D region controls H-2L and H-2M, as well as H-2D, molecules suggests that the system of H-2 antigens is more complicated. We demonstrate here previously unknown H-2 molecules detected by anti-K- and D-region alloantisera in co-capping experiments. Three different types of molecule, distinct from Ia and Qa antigens, are distinguished in the products of the Ddx region, and two in the products of the Dk and Kd regions. Analysis of the antigenic heterogeneity of K- and D-region products may further understanding of the function of these regions in cell-mediated immunity.
H-2基因复合体的K区和D区具有高度多态性，并控制参与细胞毒性T淋巴细胞H-2限制的细胞表面结构。最初人们认为这些区域各自仅控制一种类型的抗原分子，即分别为H-2K和H-2D。D区控制H-2L、H-2M以及H-2D分子这一发现表明H-2抗原系统更为复杂。我们在此展示了在共帽实验中通过抗K区和D区同种异体抗血清检测到的此前未知的H-2分子。在Ddx区的产物中可区分出三种不同于Ia和Qa抗原的分子类型，在Dk和Kd区的产物中有两种。对K区和D区产物的抗原异质性分析可能会进一步加深对这些区域在细胞介导免疫中功能的理解。
