两个紧密连锁的人白细胞干扰素基因的DNA序列

DNA sequence of two closely linked human leukocyte interferon genes.

作者信息

Lawn R M, Adelman J, Dull T J, Gross M, Goeddel D, Ullrich A

出版信息

Science. 1981 Jun 5;212(4499):1159-62. doi: 10.1126/science.6165082.

Abstract

A single recombinant lambda bacteriophage isolated from a human genome library contains two closely related human interferon genes of the leukocyte or alpha type. The two genes are separated by 12 kilobase pairs and are oriented in the same direction with respect to transcription. Comparisons of the DNA sequences of these two genes and interferon complementary DNA clones indicate that the two interferon genes lack intervening sequences.

摘要

从人类基因组文库中分离出的单个重组λ噬菌体含有两个紧密相关的白细胞或α型人干扰素基因。这两个基因相隔12千碱基对，且转录方向相同。对这两个基因的DNA序列与干扰素互补DNA克隆进行比较表明，这两个干扰素基因没有间隔序列。