Morel P A, Bergren M O, Hill V, Garratty G, Perkins H A
Transfusion. 1981 Nov-Dec;21(6):652-62. doi: 10.1046/j.1537-2995.1981.21682085751.x.
Alloagglutinins of M and N specificites with unique characteristics found in normal sera are described. Specific M or N agglutination by these sera occurred only when erythrocytes had been exposed to glucose-containing solutions. Conversion to the form of MN recognized by these sera required incubation of the cells in 1 to 2% glucose buffered to physiological or alkaline pH and was dependent on time and temperature of exposure, occurring in hours at 37 C and in days at 4 C. The sera appeared to be detecting an antigenic structure in which interaction between glucose and the amino group of the N-terminal amino acid of the MN receptor has produced a new specificity, analogous to the action of formaldehyde on N receptors and the resulting N-like structure detected by sera from hemodialysis patients.
本文描述了在正常血清中发现的具有独特特性的M和N特异性同种凝集素。这些血清的特异性M或N凝集仅在红细胞暴露于含葡萄糖溶液后才会发生。细胞在缓冲至生理或碱性pH的1%至2%葡萄糖中孵育，转化为这些血清所识别的MN形式，这取决于暴露的时间和温度，在37℃下数小时内发生，在4℃下数天内发生。这些血清似乎检测到一种抗原结构，其中葡萄糖与MN受体N端氨基酸的氨基之间的相互作用产生了一种新的特异性，类似于甲醛对N受体的作用以及血液透析患者血清所检测到的由此产生的N样结构。
